i spend quite a bit of time checking this site out and it's amazing to me that i haven't seen or heard of any defects of the s2000. certainly the 350z is well known for its mechanical problems along with many other cars.
it just makes me smile a little more to know that when i start racking up higher milage i don't have to worry about the car breaking down. Thanks Honda!

 

The car certainly has its share of quirks. Some of the severe ones are:

Oil starvation in one of the cylinders (early models)
Diff blowing up for various reasons
Power window issues
Alignment problems leading to severe tire wear
MAP sensor quirkiness
Conv. top wear holes

These at least are topics I've seen discussed to death on this website.

Edit:
I forgot to add, I have not seen any mileage-related problems though.

 

Alignment problems? hunh? Please extrapolate.

 

Alignement from the factory is horrible you should have them do an aligment of the car when you buy it to make sure it is within stocl specs...

 

You forgot to mention the other major problems with the transmission (popping out of gear) and the clutch (buzz).

For minor issues, there is the top latch rattle, the seat-belt squeak, and a thousand other annoyances.