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Sen. Kennedy has malignant brain cancer

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Old May 21, 2008 | 09:14 AM
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Default Sen. Kennedy has malignant brain cancer

This is such a sad story. This kind of cancer usually takes lives within six months. Here is what is being said:

A glioma is a brain tumor that arises from glial cells, the structural cells that surround and support the neurons that do the actual work of the brain. Aggressive gliomas, also called glioblastomas, of the type suffered by Sen. Edward M. Kennedy strike about 9,000 Americans every year, accounting for just under a third of all primary brain tumors.

With standard treatments, the median survival is 15 months, according to Dr. Keith L. Black, chairman of the department of neurosurgery at Cedars-Sinai Medical Center in Los Angeles. Two years after diagnosis, about 8% of patients are still alive. "Age is a very strong predictor of prognosis," Black said, and because Kennedy is 76, his outlook is not as good as that of someone who is younger.

The standard treatment involves surgery, radiation and chemotherapy. Surgery involves physical removal of the tumor, but that may not be a good option for Kennedy because his tumor is on the left parietal lobe, which controls language functions, such as the ability to comprehend and understand speech.

Such a tumor may sometimes cross the corpus callosum to the opposite side of the brain, making surgery even more difficult, Black said.

If the tumor is in the language areas of the brain, he said, surgeons will sometimes undertake its removal while the patient is awake so that they can monitor speech functions during the procedure.

Radiation is similar to having a brain X-ray and is given once a day, five days a week, for seven weeks.

Chemotherapy usually involves the drug Temodar, which is given orally and which is well-tolerated.

New treatments are also being studied. One experimental approach is to use the drug Avastin, which blocks the formation of new blood vessels that supply the tumor with nutrients. The drug has so far been approved only to treat colon cancer.

According to Black, about 60% of glioma patients who receive Avastin show a benefit on an MRI scan. "We believe it improves survival, and it definitely improves the quality of life," he said.

Another approach, originally developed by Black, involves the use of therapeutic vaccines. Gliomas are not recognized by the patient's immune system, so the body never mounts a defense against them.

Black developed a technique to remove proteins from the tumor and attach them to a form of white blood cell called an antigen-presenting cell, which is then injected back into the patient to activate the immune system.

In phase II studies of the vaccine, which are nearly complete, survival at two years increased from 8% to 42%, he said. Oncologists at Massachusetts General Hospital have a protocol from producing the vaccine, he added.
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Old May 21, 2008 | 09:16 AM
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0 years 0 days. . . nice.

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Old May 21, 2008 | 09:19 AM
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Sad actually, he's a good guy IMO.
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Old May 21, 2008 | 10:22 AM
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Originally Posted by s2000raj,May 21 2008, 09:19 AM
Sad actually, he's a good guy IMO.
The family of Mary Jo Kopechne might disagree.
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Old May 21, 2008 | 10:24 AM
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Originally Posted by magician,May 21 2008, 10:22 AM
The family of Mary Jo Kopechne might disagree.
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Old May 21, 2008 | 10:40 AM
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i hate to say this, b/c i never want to wish cancer on anyone, but with the amount of booz this guy has consumed is anyone surprised?
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Old May 21, 2008 | 12:38 PM
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Originally Posted by magician,May 21 2008, 11:22 AM
The family of Mary Jo Kopechne might disagree.
I hate seeing someone come down with an affliction like this but I can only feel so bad for the guy. I mean, what goes around comes around.
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Old May 21, 2008 | 02:26 PM
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Originally Posted by magician,May 21 2008, 02:22 PM
The family of Mary Jo Kopechne might disagree.
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Old May 21, 2008 | 03:49 PM
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The one thing you cannot argue with is his record in the Senate. He has consistently been behind or involved in improving the lives of the less fortunate.
He has been paying for Chapaquidik (sp) for 40 years. It cost him the presidency and is a stain on his name that will never be removed.
I am not condoning or judging what he did (or actully didn't do) but...name me one other Senator who has been as productive as he. I think maybe he has been trying to pay back since that day and has done extremely well.

My condolences go out to him and his family. His eventual death truly will be the end of an amazing families time in American history.
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Old May 21, 2008 | 03:54 PM
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Originally Posted by CrazyCracker82,May 21 2008, 02:40 PM
i hate to say this, b/c i never want to wish cancer on anyone, but with the amount of booz this guy has consumed is anyone surprised?
Considering that booze isn't connected to brain cancer, yes.
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