I am looking to buy my first S2000 and have spotted a 2

 

In my opinion there are no real weak pints in the S2000 as long as it has been driven and maintained well.
When I say well, I don't necessarily mean slowly, I mean engine on temperature before "VTEC", no clutch dumping, regular servicing, oil never left to run low, these sort of things.

So the most important factor is to by a car where you know the history.

 

Your question cannot be easily answered. You can find examples of old cars that have been daily driven and are in pristine condition where a potential buyer would have no hesitation to get. Then you'll find what was a "toy" that is one month old that has been beat to death and you would not want to touch it with a barge pole.
Check out the TSBs in the library to see what kinds of things might applied to the year of car you are after. These were general annoyances and issues that Honda thought was justified to help the owner out if brought to their attention.
As for the clutch, again, this depends on how the car was treated. I have a MY00 with about 52K KMs on it, the last 24K KMs supercharged. My clutch is working quite well and I expect it to continue for another year or two. Then you'll find a car with less than 10K miles on it and the clutch is already toast.
The best thing you can do is to have the car completedly inspected front to back, top to bottom. That is your best assurance of minimizing risk.

 

Cheers, I think I'll have an AA inspection done on the car. Thanks a lot,

 

I'm going to make your title more descriptive and move it to "S2000 Talk" since it's only vaguely UTH.