If you mean never using 1st, then no. You'll burn up your clutch every time you take off from a dead stop.

 

I am running that exact setup 322 whp, im more than happy to cruise in 6th at 35mph and not have to really downshift to get going. It makes 2nd gear feel like 1st gear used to, so you can imagine how 1st is. Def. worth it to me as a weekender car.

 

That would put you at about 2200 rpm. If you don't down shift and just punch it (and I'm saying you do this), sure, with 322 whp, you'll be able to get going, but just remember ......................
Pushing that much load at that low an rpm is a tremendous burden on main bearings, clutch assembly, tranny and rear diff. We've got a tough engine, but subjecting it to high load, low rpm will one day come back and bite ya. It doesn't matter how much power you've got, there's still the same resistence to movement. A downshift (or two) is still a wise thing to do if you really want to get moving.

 

Thanks a lot from the 4.77 carrying members! I usually travel in 6th around 40 mph. 35 is a bit low although I've done it for fun

 

I have 4.77's with the CT SC w/AC and a 7 lb pulley and I can't complain. I get through the lower RPM's to VTEC quicker which is where the SC finally kicks in. That was my theory going into it and that's what I have found to be true. It's not my DD, it's for fun and that's what it is.

As stated above, 300 HP is do able.